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KMID : 1103920120180030287
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Korean Journal of Hepatology
2012 Volume.18 No. 3 p.287 ~ p.294
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Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma
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Kwon Soon-Ha
Jeong Soung-Won
Jang Jae-Young
Lee Ji-Eun
Lee Sae-Hwan
Kim Sang-Gyune
Kim Young-Seok
Cho Young-Deok
Kim Hong-Soo
Kim Boo-Sung
Jin So-Young
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Abstract
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Background/Aims: Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and HCC.
Methods: The immunohistochemical expressions of COX-2 and VEGF were evaluated in tissues from patients with CH (n=95), cirrhosis (n=38), low-grade HCC (LG-HCC; n=6), and high-grade HCC (HG-HCC; n=29).
Results: The COX-2 expression scores in CH, cirrhosis, LG-HCC, and HG-HCC were 3.3±1.9 (mean±SD), 4.2±1.7, 5.5±1.0, and 3.4±2.4, respectively (CH vs. cirrhosis, P =0.016; CH vs. LG-HCC, P =0.008; LG-HCC vs. HG-HCC, p=0.004), and the corresponding VEGF expression scores were 0.9±0.8, 1.5±0.7, 1.8±0.9, and 1.6±1.1 (CH vs. cirrhosis, p<0.001; CH vs. LGHCC, P=0.011; LG-HCC vs. HG-HCC, P=0.075). Both factors were correlated with the fibrosis stage in CH and cirrhosis (COX-2: r=0.427, p<0.001; VEGF: r=0.491, p<0.001). There was a significant correlation between COX-2 and VEGF in all of the tissue samples (r=0.648, p<0.001), and between high COX-2 and VEGF expression scores and survival (COX-2: P=0.001; VEGF: p<0.001).
Conclusions: The expressions of both COX-2 and VEGF are significantly higher in cirrhosis and LG-HCC than in CH. High COX-2 and high VEGF expressions are associated with a high survival rate.
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KEYWORD
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Cyclooxygenase-2, Vascular endothelial growth factor, Chronic hepatitis, Liver cirrhosis, Hepatocellular carcinoma
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